Selected papers from 2000 – 2015:

A. Gdowicz-Klosok, M. Widel, J. Rzeszowska-Wolny „The influence of XPD, APE1, XRCC1, and NBS1 polymorphic variants on DNA repair in cells exposed to X-ray”. Mutation Reserch Mutation Research 755 (2013) 42– 48

P. Widłak, M. Pietrowska, J. Polańska, T. Rutkowski, K. Jelonek, M. Kalinowska-Herok, A. Gdowicz-Kłosok, A. Wygoda, R. Tarnawski and K. Składowski „Radiotherapy-related changes in serum proteome patterns of head and neck cancer patients; the effect of low and medium doses of radiation delivered to large volumes of normal tissue" Journal of Transation Medicine 2013, 11:299

D. Mielzynska-Svach , E. Blaszczyk , D. Butkiewicz , J. Durzynska , M. Rydzanicz „Influence of genetic polymorphisms on biomarkers of exposure and effects in children living in Upper Silesia” Mutagenesis. 2013 Sep;28(5):591-9. doi: 10.1093/mutage/get037. Epub 2013 Jul 18.

M. Krześniak, A. Zajkowicz, I. Matuszczyk, M. Rusin Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mech Ageing Dev. 2014,  139, 11-21.

M. Pietrowska, K. Jelonek, M. Michalak, M. Roś, P. Rodziewicz, K. Chmielewska, K. Polański, J. Polańska, A. Gdowicz-Kłosok, M. Giglok, R. Suwiński, R. Tarnawski, R. Dziadziuszko, W. Rzyman, P. Widłak “Identification of serum proteome components associated with progression of non-small cell lung cancer.” Acta Biochim Pol.  2014, 61:325-331

D. Scieglinska , A. Gogler-Piglowska , D. Butkiewicz , M. Chekan , E. Malusecka , J. Harasim , A. Habryka , Z. Krawczyk  „HSPA2 is expressed in human tumors and correlates with clinical features in non-small cell lung carcinoma patients.” Anticancer Res. 2014 Jun;34(6):2833-40.

D. Butkiewicz, M. Krześniak, A. Drosik, M. Giglok, A. Gdowicz-Kłosok, A. Kosarewicz, M. Rusin, B. Masłyk, M. Gawkowska-Suwińska, R. Suwiński “The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. Int J Cancer. 137(10) 2015, 2332-42

A. Zajkowicz, A. Gdowicz-Kłosok, M. Krześniak, D. Ścieglińska, M. RusinActinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.Cell Signal. 27(9) 2015, 1677-87.

A. Gdowicz-Klosok, M. Giglok, A. Drosik, R. Suwiński, D. Butkiewicz „The SIPA1 -313A>G polymorphism is associated with prognosis in inoperable non-small cell lung cancer.” Tumor Biol. February 2015, Volume 36, Issue 2, pp 1273-1278

A. Abramowicz, A. Wojakowska, A. Gdowicz-Klosok, J. Polanska, P. Rodzewicz, P. Polanowski, A. Namysl-Kaletka, M. Pietrowska, J. Wydmanski, P. Widlak „Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study.” Journal of Translational Medicine 2015, 13:304

Zajkowicz A, Krześniak M, Matuszczyk I, Głowala-Kosińska M, Butkiewicz D, Rusin M. Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol. Mol Biol Rep. 2013 May 11. [Epub ahead of print]

Butkiewicz D, Drosik A, Suwiński R, Krześniak M, Rusin M, Kosarewicz A, Rachtan J, Matuszczyk I, Gawkowska-Suwińska M. Influence of DNA repair gene polymorphisms on prognosis in inoperable non-small cell lung cancer patients treated with radiotherapy and platinum-based chemotherapy. Int J Cancer. 2012 Oct 1;131(7):E1100-8.

Zajkowicz A, Rusin M. The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. Mech Ageing Dev. 2011 Nov-Dec;132(11-12):543-51.

Butkiewicz D, Rusin M, Sikora B, Lach A, Chorąży M. An association between DNA repair gene polymorphisms and survival in patients with resected non-small cell lung cancer. Mol Biol Rep. 2011 Nov;38(8):5231-41.

Varadi V, Bevier M, Grzybowska E, Johansson R, Enquist K, Henriksson R, Butkiewicz D, Pamula-Pilat J, Tecza K, Hemminki K, Lenner P, Försti A. Genetic variation in genes encoding for polymerase ? subunits associates with breast cancer risk, tumour characteristics and survival. Breast Cancer Res Treat. 2011 Aug;129(1):235-45.

Butkiewicz D, Krześniak M, Vaitiekunaite R, Sikora B, Bowman ED, Harris CC, Rusin M. A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene. Cell Mol Biol Lett. 2010 Dec;15(4):611-29.

Rusin M, Zajkowicz A, Butkiewicz D. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech Ageing Dev. 2009 Aug;130(8):528-37.

Cote ML, Chen W, Smith DW, Benhamou S, Bouchardy C, Butkiewicz D, Fong KM, Gené M, Hirvonen A, Kiyohara C, Larsen JE, Lin P, Raaschou-Nielsen O, Povey AC,Reszka E, Risch A, Schneider J, Schwartz AG, Sorensen M, To-Figueras J, Tokudome S, Pu Y, Yang P, Wenzlaff AS, Wikman H, Taioli E. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am J Epidemiol. 2009 Apr 1;169(7):802-14.

Wikman H, Taioli E. Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am J Epidemiol. 2009 Apr 1;169(7):802-14.

Vaitiekunaite R, Butkiewicz D, Krześniak M, Przybyłek M, Gryc A, Snietura M, Benedyk M, Harris CC, Rusin M. Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. Mech Ageing Dev. 2007 Nov-Dec;128(11-12):650-61.

Popanda O, Edler L, Waas P, Schattenberg T, Butkiewicz D, Muley T, Dienemann H, Risch A, Bartsch H, Schmezer P. Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms. Lung Cancer. 2007 Jan;55(1):25-34.

Pamuła J, Krześniak M, Zientek H, Pekala W, Rusin M, Grzybowska E. Functional Impact of Sequence Alterations Found in BRCA1 Promoter/5'UTR Region in Breast/Ovarian Cancer Families from Upper Silesia, Poland. Hered Cancer Clin Pract. 2006 Jan 15;4(1):20-4.

Wagner K, Hemminki K, Grzybowska E, Bermejo JL, Butkiewicz D, Pamula J, Pekala W, Försti A. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer. Int J Cancer. 2006 Jun 1;118(11):2903-6.

Sengupta S, Shimamoto A, Koshiji M, Pedeux R, Rusin M, Spillare EA, Shen JC, Huang LE, Lindor NM, Furuichi Y, Harris CC. Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene. 2005 Mar 3;24(10):1738-48.

Rzeszowska-Wolny J, Polanska J, Pietrowska M, Palyvoda O, Jaworska J, Butkiewicz D, Hancock R. Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. Radiat Res. 2005 Aug;164(2):132-40.

Raimondi S, Boffetta P, Anttila S, Bröckmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Dragani TA, Garte S, Gsur A, Haidinger G, Hirvonen A, Ingelman-Sundberg M, Kalina I, Lan Q, Leoni VP, Le Marchand L, London SJ, Neri M, Povey AC, Rannug A, Reszka E, Ryberg D, Risch A, Romkes M, Ruano-Ravina A, Schoket B, Spinola M, Sugimura H, Wu X, Taioli E. Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res. 2005 Dec 30;592(1-2):45-57.

Łobocka MB, Rose DJ, Plunkett G 3rd, Rusin M, Samojedny A, Lehnherr H, Yarmolinsky MB, Blattner FR. Genome of bacteriophage P1. J Bacteriol. 2004 Nov;186(21):7032-68.

Krześniak M, Butkiewicz D, Samojedny A, Chorazy M, Rusin M. Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet. 2004 Jul;68(Pt 4):300-12.

Rusin M, Zientek H, Krześniak M, Małusecka E, Zborek A, Krzyzowska-Gruca S, Butkiewicz D, Vaitiekunaite R, Lisowska K, Grzybowska E, Krawczyk Z. Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk. Mol Carcinog. 2004 Mar;39(3):155-63.

Butkiewicz D, Popanda O, Risch A, Edler L, Dienemann H, Schulz V, Kayser K, Drings P, Bartsch H, Schmezer P. Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene. Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2242-6.

Vineis P, Veglia F, Benhamou S, Butkiewicz D, Cascorbi I, Clapper ML, Dolzan V, Haugen A, Hirvonen A, Ingelman-Sundberg M, Kihara M, Kiyohara C, Kremers P, Le Marchand L, Ohshima S, Pastorelli R, Rannug A, Romkes M, Schoket B, Shields P, Strange RC, Stucker I, Sugimura H, Garte S, Gaspari L, Taioli E. CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls. Int J Cancer. 2003 May 1;104(5):650-7.

Seker H, Butkiewicz D, Bowman ED, Rusin M, Hedayati M, Grossman L, Harris CC. Functional significance of XPD polymorphic variants: attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype. Cancer Res. 2001 Oct 15;61(20):7430-4.

Butkiewicz D, Rusin M, Enewold L, Shields PG, Chorazy M, Harris CC. Genetic polymorphisms in DNA repair genes and risk of lung cancer. Carcinogenesis. 2001 Apr;22(4):593-7.

Butkiewicz D, Rusin M, Harris CC, Chorazy M. Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population. Hum Mutat. 2000 Jun;15(6):577-8.