Heat Shock ProteinsDr Dorota Ścieglińska Lab

Heat Shock Proteins (HSP)

are molecular chaperones maintaining cellular proteome homeostasis under stressful and physiological conditions. In humans, the


family is the most abundant HSP family consisting of at least thirteen highly homologous genes, which are constitutively expressed and/or their expression can be activated in response to various pathological conditions and environmental stress. The HSPAs expressed constitutively play the role of housekeeping molecular chaperones required for proper folding and activity of multiple cellular proteins. HSPA proteins are known as cytoprotective agents able to cope with various stress conditions. Their activity is beneficial for survival of normal and pathologically transformed cells.

Expression of many HSPA proteins is changed in cancer cells. Carcinogenesis is linked to stress caused by disturbances in signaling pathways and cellular metabolism. Altered expression of many HSPs is an important factor which modulates the phenotype of cancer cells. Characterization of molecular processes which have been modified by HSP activity would enable better understanding of complexity of carcinogenesis.

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The team consists of researchers experienced in molecular and cellular biology. Their expertise spans the following research techniques: