Center for Translational Research and Molecular Biology of Cancer was founded in 2010 after the reorganization of the Research Division of Institute of Oncology in Gliwice.

Research interests. Scientific activities of the Center focus on research in the field of the molecular biology of cancer and translation of research results into clinical practice (i.e., translational research in short). The general goals of the Center are focused on the bases of novel methods of molecular diagnostics and anticancer therapies. Specifically, research topics include: (i) genetic risk factor in cancer predisposition, (ii) novel prognostic and predictive markers for cancer therapy; (iii) genomic, proteomic and metabolome signatures for cancer identification and classification; (iv) pharmacology and biology of novel anticancer factors; (v) novel vectors and strategies of drug delivery. Another group of basic research projects is related mostly to molecular responses to cellular stress, including crosstalk between transcription and regulatory networks active in cancer cells. For more detailed information about research projects visit pages of research groups forming the Center.

Researchers

The Center is staffed by a group of experienced researchers, doctoral students and technical employees (more than 50 people in total). The core of the Center staff is a group of about 40 scientists with various academic backgrounds (biologists, biotechnologists, physicians, chemists, physicists, and computer scientists). Currently, the Center employs thirteen professors and about 25 postdocs. They supervise the work of doctoral students, undergraduate students and volunteers. The researchers make extensive use of advanced molecular and cell biology techniques and methods. Generally, areas of their skill and research experience cover gene expression analyses (based on microarrays and QRT-PCR methods), DNA sequencing, structural and functional gene studies, gene cloning, fusion/recombinant proteins, stem cells, tumor hypoxia, novel experimental antitumor strategies (involving the tumor microenvironment, immune suppression or drug nanocarriers), live-cell microscopy as well as proteomic and metabolomic approaches based on mass spectrometry. The Center is organized into several laboratory research teams. For more detailed information concerning individual research groups (staff, research grant projects and research papers) visit their web pages.

Research Collaboration The Center actively collaborates with several Polish and foreign cancer research entities. The latter include such renowned establishments as Deutsches Krebsforschungszentrum (DKFZ, Heidelberg), National Cancer Institute (NCI, Bethesda), UT Southwestern Medical Center (Dallas), and MD Anderson Cancer Center (Houston). Close research ties are maintained between the Center and scientists from the Silesian University of Technologies in Gliwice (especially the Faculty of Automatic Control, Electronics and Computer Science, and the Center of Biotechnology), as well as investigators from research units participating in the works of BioMedtech Silesia Center of Excellence Network. Our researchers have also been involved in supporting undergraduate and graduate educational mission by serving as lecturers and instructors in academic programs offered by three Silesian institutions of higher learning: the University of Silesia in Katowice, the Medical University of Silesia and the Silesian University of Technology in Gliwice. The majority of research projects implemented at the Center are pursued in close collaboration with teams of physicians from different clinics or clinical departments at the parent institution.

History of the Research Division. Research in the field of cancer biology has been conducted at the Gliwice Branch of the Maria Skłodowska-Curie Memorial Institute of Oncology since 1948 when the Department of Tumor Biopathology was founded. This department was soon after transformed into the Department of Tumor Biology. Between 1997 and 2010 the Research Division of the Institute of Oncology in Gliwice consisted of three departments: Molecular Biology, Tumor Biology and Experimental & Clinical Radiobiology. In 2004, the Research Division has been granted the "Center of Excellence" status by the Ministry of Science and Informatization (as one of two institutions in Poland involved in oncology-oriented research). In 2010, the internal structure of the Research Division was revamped. In lieu of the three previously existing departments, a new Center for Translational Research and Molecular Biology of Cancer was formed. More history